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Protein restriction during peripubertal period impairs endothelial aortic function in adult male Wistar rats. | LitMetric

AI Article Synopsis

  • Protein restriction during the peripubertal period (ages 30-60 days in rats) was studied to see if it leads to endothelial dysfunction later in adulthood.
  • Male Wistar rats were fed either a normal protein diet (23%) or a low protein diet (4%) and then their aorta responses were tested when they reached maturity (age 120 days).
  • Results indicated that low protein intake was linked to increased sensitivity to phenylephrine (a vasoconstrictor) and higher oxidative stress markers, suggesting that early protein restriction can negatively affect vascular health in adulthood.

Article Abstract

Protein restriction during early phases of body development, such as intrauterine life can favor the development of vascular disorders. However, it is not known if peripubertal protein restriction can favor vascular dysfunction in adulthood. The present study aimed to evaluated whether a protein restriction diet during peripubertal period favors endothelial dysfunction in adulthood. Male Wistar rats from postnatal day (PND) 30 until 60 received a diet with either 23% protein (CTR group) or with 4% protein (LP group). At PND 120, the thoracic aorta reactivity to phenylephrine, acetylcholine, and sodium nitroprusside was evaluated in the presence or absence of: endothelium, indomethacin, apocynin and tempol. The maximum response (Rmax) and pD2 (-log of the concentration of the drug that causes 50% of the Rmax) were calculated. The lipid peroxidation and catalase activity were also evaluated in the aorta. The data were analyzed by ANOVA (one or two-ways and Tukey's) or independent -test; the results were expressed as mean ± S.E.M., < 0.05. The Rmax to phenylephrine in aortic rings with endothelium were increased in LP rats when compared with the Rmax in CTR rats. Apocynin and tempol reduced Rmax to phenylephrine in LP aortic rings but not in CTR. The aortic response to the vasodilators was similar between the groups. Aortic catalase activity was lower and lipid peroxidation was greater in LP compared to CTR rats. Therefore, protein restriction during the peripubertal period causes endothelial dysfunction in adulthood through a mechanism related to oxidative stress.

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Source
http://dx.doi.org/10.1017/S2040174423000119DOI Listing

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