AI Article Synopsis
- Helicobacter pylori's CagA can lead to gastric mucosal atrophy (GMA) and cancer, while host cells utilize autophagy to degrade it.
- A study involving 200 H. pylori-positive individuals found significant genetic associations between SNPs in autophagy-related genes (LRP1 and CAPAZ1) and GMA risk.
- Specifically, certain genotypes increased susceptibility to GMA, suggesting potential targets for precision medicine in managing individuals at risk.
Article Abstract
Background: Helicobacter pylori secretes cytotoxin-associated gene A (CagA) into the gastric epithelium, causing gastric mucosal atrophy (GMA) and gastric cancer. In contrast, host cells degrade CagA via autophagy. However, the association between polymorphisms in autophagy-related genes and GMA must be fully elucidated.
Results: We evaluated the association between single nucleotide polymorphisms (SNPs) in autophagy-related genes (low-density lipoprotein receptor-related protein 1, LRP1; capping actin protein of muscle Z-line alpha subunit 1, CAPAZ1; and lysosomal-associated membrane protein 1, LAMP1) and GMA in 200 H. pylori-positive individuals. The frequency of the T/T genotype at rs1800137 in LRP1 was significantly lower in the GMA group than in the non-GMA group (p = 0.018, odds ratio [OR] = 0.188). The frequencies of the G/A or A/A genotype at rs4423118 and T/A or A/A genotype at rs58618380 of CAPAZ1 in the GMA group were significantly higher than those in the non-GMA group (p = 0.029 and p = 0.027, respectively). Multivariate analysis revealed that C/C or C/T genotype at rs1800137, T/A or A/A genotype at rs58618380, and age were independent risk factors for GMA (p = 0.038, p = 0.023, and p = 0.006, respectively). Furthermore, individuals with the rs1800137 C/C or C/T genotype of LRP1 had a 5.3-fold higher susceptibility to GMA. These genetic tests may provide future directions for precision medicine for individuals more likely to develop GMA.
Conclusion: LRP1 and CAPZA1 polymorphisms may be associated with the development of GMA.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189954 | PMC |
| http://dx.doi.org/10.1186/s41021-023-00274-5 | DOI Listing |
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