AI Article Synopsis
- * Treatment with these cells restored erectile function and aided the recovery of important penile tissues and nerves.
- * Results showed less fibrosis in the penis, suggesting this therapy is a promising approach for addressing erectile dysfunction from nerve injuries.
Article Abstract
Background: This study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerve injury.
Results: The skin-derived precursor Schwann cells-treatment significantly restored erectile functions, accelerated the recovery of endothelial and smooth muscle tissues in the penis, and promoted nerve repair. The expression of p-Smad2/3 decreased after the treatment, which indicated significantly reduced fibrosis in the corpus cavernosum.
Conclusions: Implantation of skin-derived precursor Schwann cells is an effective therapeutic strategy for treating erectile dysfunction induced by bilateral cavernous nerve injury.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193723 | PMC |
| http://dx.doi.org/10.1186/s12610-023-00187-x | DOI Listing |
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