Old T cells pollute with mito-litter.

Nat Aging

Homeostasis de Tejidos y Órganos, Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas (CSIC) and Universidad Autónoma de Madrid, Madrid, Spain.

Published: May 2023

The mysteries behind immune aging and its related inflammation are being unmasked. The research of Jin et al. reveals that the defective turnover of damaged mitochondria in CD4 T cells from aged individuals results in the exacerbated secretion of mitochondrial DNA, fuelling inflammaging and impairing immune responses.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615384PMC
http://dx.doi.org/10.1038/s43587-023-00412-2DOI Listing

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