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GnRH pulse generator activity in mouse models of polycystic ovary syndrome.
Elife
January 2025
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
One in ten women in their reproductive age suffer from polycystic ovary syndrome (PCOS) that, alongside subfertility and hyperandrogenism, typically presents with increased luteinizing hormone (LH) pulsatility. As such, it is suspected that the arcuate kisspeptin (ARN) neurons that represent the GnRH pulse generator are dysfunctional in PCOS. We used here in vivo GCaMP fiber photometry and other approaches to examine the behavior of the GnRH pulse generator in two mouse models of PCOS.
View Article and Find Full Text PDFTwenty-one Years of Undergraduate Medical Student Research Training at the University of the Free State (UFS), South Africa.
Med Sci Educ
December 2024
Department of Biostatistics, School of Biomedical Sciences, Faculty of Health Sciences, University of the Free State, 205 Nelson Mandela Drive, Bloemfontein, 9300 South Africa.
Introduction: Since 2001, undergraduate medical students at the University of the Free State (UFS), South Africa, plan, perform, and report on their research projects during semesters 2-5 of their ten-semester training. We describe the research modules and review the projects of the first 21 years.
Methods: This cohort study included all undergraduate medical student projects that formed part of the first 21 presentations of the research modules.
Deep learning-based object detection algorithms in medical imaging: Systematic review.
Heliyon
January 2025
NOVA Information Management School, Lisboa, Portugal.
Over the past decade, Deep Learning (DL) techniques have demonstrated remarkable advancements across various domains, driving their widespread adoption. Particularly in medical image analysis, DL received greater attention for tasks like image segmentation, object detection, and classification. This paper provides an overview of DL-based object recognition in medical images, exploring recent methods and emphasizing different imaging techniques and anatomical applications.
View Article and Find Full Text PDFPathogen stress heightens sensorimotor dimensions in the human collective semantic space.
Commun Psychol
January 2025
State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.
Infectious diseases have been major causes of death throughout human history and are assumed to broadly affect human psychology. However, whether and how conceptual processing, an internal world model central to various cognitive processes, adapts to such salient stress variables remains largely unknown. To address this, we conducted three studies examining the relationship between pathogen severity and semantic space, probed through the main neurocognitive semantic dimensions revealed by large-scale text analyses: one cross-cultural study (across 43 countries) and two historical studies (over the past 100 years).
View Article and Find Full Text PDFPredicting hepatocellular carcinoma outcomes and immune therapy response with ATP-dependent chromatin remodeling-related genes, highlighting MORF4L1 as a promising target.
Cancer Cell Int
January 2025
Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Hepatobiliary Cancers, Nanjing, Jiangsu, China.
Background: Hepatocellular carcinoma (HCC) continues to be a major cause of cancer-related death worldwide, primarily due to delays in diagnosis and resistance to existing treatments. Recent research has identified ATP-dependent chromatin remodeling-related genes (ACRRGs) as promising targets for therapeutic intervention across various types of cancer. This development offers potential new avenues for addressing the challenges in HCC management.
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