AI Article Synopsis
- - Periodontitis is a common and destructive disease linked to other systemic health issues, with current treatments facing challenges like drug resistance and poor effectiveness.
- - A new dual-functional polypeptide, LL37-C15, has been developed, demonstrating strong antibacterial properties against key bacteria involved in periodontitis and reducing inflammation by inhibiting pro-inflammatory cytokines.
- - In vivo studies in a rat model show that LL37-C15 effectively preserves alveolar bone and selectively targets bacterial membranes while protecting animal cells, highlighting its potential as a novel treatment for periodontitis and other inflammatory diseases.
Article Abstract
Periodontitis has been reported as the sixth most prevalent disease in human beings. This destructive disease is closely related to systemic diseases. Existing local drug delivery systems for periodontitis suffer from poor antibacterial effect and drug resistance. Inspired by the pathogenesis of periodontitis, we implemented a strategy to construct a dual functional polypeptide LL37-C15, which exhibited remarkable antibacterial effect against P. gingivalis and A. actinomycetemcomitans. In addition, LL37-C15 inhibits the release of pro-inflammatory cytokines by controlling the inflammatory pathway and reversing macrophage M1. Furthermore, the anti-inflammatory effect of LL37-C15 was also verified in vivo in a periodontitis rat model through the morphometry and histological observations of alveolar bone, hematoxylin-eosin, and Trap staining in gingival tissue. The results of molecular dynamics simulations showed that LL37-C15 could selectively destroy the bacterial cell membrane and protect the animal cell membrane in a self-destructive manner. The results showed that the polypeptide LL37-C15, as a novel promising therapeutic agent, exhibited a great potential for the periodontitis management. What's more, this dual functional polypeptide provides a promising strategy for building a multifunctional therapeutic platform against the inflammation and other diseases.
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| http://dx.doi.org/10.1016/j.ijbiomac.2023.124920 | DOI Listing |
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