Swanton et al. find that PM exposure is associated with EGFR/KRAS-driven lung cancer incidence. PM increases EGFR pre-mutated alveolar type II cell progenitor function and tumorigenic activity through interstitial macrophage-secreted IL-1β, providing potential prevention approaches to inhibit cancer initiation.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213952 | PMC |
| http://dx.doi.org/10.1016/j.xcrm.2023.101046 | DOI Listing |
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