Background: This investigation studied the impacts of the miR-30a-5p/CBX2 axis on esophageal cancer (EC).
Methods: Research objects were ascertained using The Cancer Genome Atlas database. Followed by qRT-PCR, western blot, dual-luciferase reporter, MTT, Transwell, and wound healing approaches, we tested gene expression and varying cell behaviors RESULTS: Conspicuously miR-30 family members (miR-30a-5p, miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-30e-5p) downregulation and CBX2 upregulation were discovered in EC cells. miR-30 family members target CBX2 and inhibited CBX2 expression. EC cell behaviors were inhibited by miR-30a-5p/CBX2 axis.
Conclusion: MiR-30a-5p draws a new inspiration for EC treatment.
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| http://dx.doi.org/10.1016/j.mrfmmm.2023.111818 | DOI Listing |
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