Purpose Of Review: Considering the increase in life expectancy, there is a time-related decline in biological functions. Age-related changes are also observed in the circadian clock which directly leads to appropriate rhythms in the endocrine and metabolic pathways required for organism homeostasis. Circadian rhythms are affected by the sleep/wake cycle, environmental changes, and nutrition. The aim of this review is to show the relationship between age-related changes in circadian rhythms of physiological and molecular processes and nutritional differences in the elderly.
Recent Findings: Nutrition is an environmental factor that is particularly effective on peripheral clocks. Age-related physiological changes have an impact on nutrient intake and circadian processes. Considering the known effects of amino acid and energy intakes on peripheral and circadian clocks, it is thought that the change in circadian clocks in aging may occur due to anorexia due to physiological changes.
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http://dx.doi.org/10.1007/s13668-023-00474-z | DOI Listing |
Drugs Aging
January 2025
Program for the Care and Study of the Aging Heart, Department of Medicine, Weill Cornell Medicine, 420 East 70th St, New York, NY, LH-36510063, USA.
There are several pharmacologic agents that have been touted as guideline-directed medical therapy for heart failure with preserved ejection fraction (HFpEF). However, it is important to recognize that older adults with HFpEF also contend with an increased risk for adverse effects from medications due to age-related changes in pharmacokinetics and pharmacodynamics of medications, as well as the concurrence of geriatric conditions such as polypharmacy and frailty. With this review, we discuss the underlying evidence for the benefits of various treatments in HFpEF and incorporate key considerations for older adults, a subpopulation that may be at higher risk for adverse drug events.
View Article and Find Full Text PDFGeroscience
January 2025
Buck Institute for Research On Aging, Novato, CA, 94945, USA.
Cells are subjected to dynamic mechanical environments which impart forces and induce cellular responses. In age-related conditions like pulmonary fibrosis, there is both an increase in tissue stiffness and an accumulation of senescent cells. While senescent cells produce a senescence-associated secretory phenotype (SASP), the impact of physical stimuli on both cellular senescence and the SASP is not well understood.
View Article and Find Full Text PDFBrain Res Bull
January 2025
Department of Health, Graduate School, Dankook University, 119, Dandae-ro, Dongnam-gu, Cheonan-si, Chungnam, 31116, Republic of Korea. Electronic address:
Introduction: The thalamus regulates various sensory information to each related brain area. The vestibular nucleus transmits information of motor control to the thalamus regulating coordination function. The vestibulothalamic tract (VTT) is a neural pathway between the vestibular nucleus and thalamus that processes vestibular information for postural balance and spatial perception.
View Article and Find Full Text PDFMethods Mol Biol
January 2025
Department of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Aging adversely affects the self-renewal and differentiation capabilities of stem cells, which impairs tissue regeneration as well as the homeostasis. Epigenetic mechanisms, specifically DNA methylation, play a key role in the maintenance of pluripotency in stem cells and regulation of pluripotency-related gene expression. Age-related modifications in methylation patterns could influence the expression of genes critical for stem cell potency maintenance, including transcription factors Nanog and Sox2.
View Article and Find Full Text PDFGeroscience
January 2025
Keldysh Institute of Applied Mathematics, Russian Academy of Sciences, Moscow, 125047, Russia.
Age-related dependencies of electric and spectral powers in conventional frequency bands were studied by the newly proposed method of detailed spectral analysis. The magnetic encephalograms (MEG) and magnetic resonance images (MRI) of the head were obtained from the open archive Cam-CAN. The spatial distributions of elementary spectral components (MEG-based functional tomograms) were reconstructed from MEG for 501 subjects (248 males and 253 females, ages 18-88 years, mean age 54.
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