We present a highly efficient and practical method for synthesizing -dibromo 1,3-oxazines through 6- cyclization of propargylic amides, using -bromosuccinimide (NBS) as an electrophilic source. The metal-free reaction can be conducted under mild conditions with good functional group compatibility, delivering excellent yields of the desired products. Mechanistic studies suggest that the reaction proceeds a double electrophilic attack by NBS on the propargylic amide substrate.
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