Bipolar disorder, a mental illness that affects mood, behavior, and motivation is characterized by alternating depressive and manic (hypomanic) episodes (some mixed episodes include both types of symptoms), with periods of remission between episodes. Symptoms and progress vary across patients. Treatment includes anti-seizure medications and maintenance therapy to prevent seizures. Classically, lithium carbonate and valproate are the most commonly used medications; however, in addition to lamotrigine, atypical antipsychotics including aripiprazole, quetiapine, and lurasidone are being used in recent years. Theoretically, patients are administered monotherapy; however, it is not uncommon to use combination treatment in clinical practice.
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http://dx.doi.org/10.11477/mf.1416202386 | DOI Listing |
ISME J
January 2025
Evolutionary Ecology of Plants, Department of Biology, University of Marburg, 35043 Marburg, Germany.
Land-use changes threaten ecosystems and are a major driver of species loss. Plants may adapt or migrate to resist global change, but this can lag behind rapid anthropogenic changes to the environment. Our data show that natural modulations of the microbiome of grassland plants in response to experimental land-use change in a common garden directly affect plant phenotype and performance, thus increasing plant tolerance.
View Article and Find Full Text PDFChaos
January 2025
School of Science, Chongqing University of Posts and Telecommunications, Chongqing 400065, China.
Humans and predators occupy dominant positions in ecosystems and are generally believed to play a decisive role in maintaining ecosystem stability, particularly in the context of virus transmission. However, this may not always be the case. By establishing some ecosystem virus transmission models that cover both human perspectives and predators, we have drawn the following conclusions: (1) Controlling vaccination activities from the human perspective can potentially lower the transmission rate and improve herd immunity, thereby indirectly protecting unvaccinated risk groups.
View Article and Find Full Text PDFFront Bioeng Biotechnol
January 2025
Department of Physical Education, Tsinghua University, Beijing, China.
Purpose: Plantar soft tissue properties affect foot biomechanics during movement. This study aims to explore the relationship between plantar pressure features and soft tissue stiffness through interpretable neural network model. The findings could inform orthotic insole design.
View Article and Find Full Text PDFBMC Geriatr
January 2025
Department of Orthopaedics, Kasturba Medical College, Manipal, Karnataka, 576104, India.
Introduction: Mental disorders are prevalent among older adults, often leading to the use of multiple medications, many with anticholinergic properties. Polypharmacy, common in this population, is a major contributor to anticholinergic burden, which is linked to cognitive and physical decline. This study investigates the relationship between polypharmacy and anticholinergic burden across seven anticholinergic burden scales in elderly patients attending the psychiatric outpatient.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing 210094, China; Key Laboratory of Metabolic Engineering and Biosynthesis Technology, Ministry of Industry and Information Technology, 210094, China. Electronic address:
The structure of soft tissues is often destroyed by injury and aging. Injectable fillers eliminate the need for surgery and enhance repair. Hyaluronic acid-based hydrogels are commonly employed for their effectiveness and biocompatibility.
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