AI Article Synopsis
- Increased sperm DNA fragmentation (SDF) negatively affects fertility, leading to lower pregnancy and delivery rates in both natural conception and assisted reproduction methods like intrauterine insemination and in-vitro fertilization.
- Although high SDF does not impact fertilization or pregnancy rates with intracytoplasmic sperm injection (ICSI), it is associated with poorer embryo quality and a higher likelihood of miscarriage.
- The article reviews various sperm selection techniques aimed at improving DNA quality for assisted reproductive technology, discussing their principles, benefits, and limitations.
Article Abstract
The body of evidence supports the negative impact of increased sperm DNA fragmentation (SDF) on natural fertility as well as assisted reproduction conditions. High SDF has been correlated with low pregnancy and delivery rates following intrauterine insemination. Also, high SDF is accused of reducing the rates of fertilization, implantation, pregnancy, and live birth following in-vitro fertilization (IVF). Despite no impact of high SDF on fertilization or pregnancy rates following intracytoplasmic sperm injection (ICSI), it has been correlated with poor embryo quality and a higher risk of miscarriage. Several methods have been introduced to help select sperm with the best DNA quality to be used in assisted reproductive technology procedures. These include magnetic-activated cell sorting, intracytoplasmic morphologically selected sperm injection, physiologic ICSI, and microfluidic sperm sorters, among others. This article aimed to discuss the impact of high SDF in infertile men on the reproductive outcome of couples undergoing IVF/ICSI. Additionally, this review highlights the principles, advantages, and limitations of different techniques that are currently used for the selection of sperm with intact DNA to be utilized for ICSI.
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| http://dx.doi.org/10.23736/S0031-0808.23.04870-X | DOI Listing |
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