Getting the next generation to participate in chemistry will require dismantling normative approaches to education and mentoring. Inclusive pedagogy that incorporates social issues and innovative teaching with special attention to historically excluded groups are keys to unlocking the full potential of future scientists.
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http://dx.doi.org/10.1038/s41570-023-00503-z | DOI Listing |
J Med Chem
January 2025
The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Second Military Medical University (Naval Medical University), 325 Guohe Road, Shanghai 200433, China.
Invasive candidiasis has attracted global attention with a high incidence and mortality. Current antifungal drugs are limited by unfavorable therapeutic efficacy, significant hepatorenal toxicity, and the development of drug resistance. Herein, we designed the first generation of lanosterol 14α-demethylase (CYP51)/heat shock protein 90 (Hsp90) dual inhibitors on the basis of antifungal synergism.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Chemistry, City University of Hong Kong, Kowloon, Hong Kong, China.
Prussian blue analogs (PBAs), as a classical kind of microporous materials, have attracted substantial interests considering their well-defined framework structures, unique physicochemical properties and low cost. However, PBAs typically adopt cubic structure that features small pore size and low specific surface area, which greatly limits their practical applications in various fields ranging from gas adsorption/separation to energy conversion/storage and biomedical treatments. Here we report the facile and general synthesis of unconventional hexagonal open PBA structures.
View Article and Find Full Text PDFBrief Bioinform
November 2024
Department of Computer Science, Hunan University, Changsha 410008, China.
Recently, the impressive performance of large language models (LLMs) on a wide range of tasks has attracted an increasing number of attempts to apply LLMs in drug discovery. However, molecule optimization, a critical task in the drug discovery pipeline, is currently an area that has seen little involvement from LLMs. Most of existing approaches focus solely on capturing the underlying patterns in chemical structures provided by the data, without taking advantage of expert feedback.
View Article and Find Full Text PDFChem Rev
January 2025
Division of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan.
Metal nanomaterials with unconventional phases have been recently developed with a variety of methods and exhibit novel and attractive properties such as high activities for various catalytic reactions and magnetic properties. In this review, we discuss the progress and the trends in strategies for synthesis, crystal structure, and properties of phase-controlled metal nanomaterials in terms of elements and the combination of alloys. We begin with a brief introduction of the anomalous phase behavior derived from the nanosize effect and general crystal structures observed in metal nanomaterials.
View Article and Find Full Text PDFOphthalmic Plast Reconstr Surg
January 2025
Department of Ophthalmology, Warrington Hospital, Warrington, United Kingdom.
Purpose: The study aimed to assess the efficacy and recurrence rate of everting sutures as a sole procedure in entropion repair, its impact on quality of life during the coronavirus disease pandemic, and to determine if this procedure remains an option to offer after the pandemic.
Design: Retrospective clinical cohort study.
Methods: Retrospective study of 58 patients who had everting sutures for entropion repair over a 1-year period.
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