A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 143

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 994
Function: getPubMedXML

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3134
Function: GetPubMedArticleOutput_2016

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Increased Histological Tumor Pigmentation in Uveal Melanoma Is Related to Eye Color and Loss of Chromosome 3/BAP1. | LitMetric

AI Article Synopsis

  • A study investigated the relationship between tumor pigmentation and survival in patients with uveal melanoma (UM), finding that increased pigmentation correlates with higher mortality rates.
  • The research included 1,058 patients and analyzed various factors, such as genetic features and clinical outcomes related to pigmentation levels.
  • Although pigmentation was associated with chromosome abnormalities, it was not an independent prognostic factor when accounting for genetic status, suggesting that other markers, like BRCA-related protein loss and PRAME expression, may be more relevant for prognosis.

Article Abstract

Purpose: Heavy pigmentation is known to be a prognostic risk factor in uveal melanoma (UM). We analyzed whether genetic tumor parameters were associated with tumor pigmentation and whether pigmentation should be included in prognostic tests.

Design: Retrospective comparison of clinical, histopathological, and genetic features and survival in UM with different pigmentation.

Participants: A total of 1058 patients with UM from a White European population with diverse eye colors enucleated between 1972 and 2021.

Methods: Cox regression and log-rank tests were used for survival analysis; the chi-square test and Mann-Whitney test were used for correlation analysis.

Main Outcome Measures: Uveal melanoma-related survival based on tumor pigmentation and chromosome status, correlation of tumor pigmentation with prognostic factors.

Results: The 5-year UM-related mortality was 8% in patients with nonpigmented tumors (n = 54), 25% with lightly pigmented tumors (n = 489), 41% with moderately pigmented tumors (n = 333), and 33% with dark tumors (n = 178) ( < 0.001). The percentage of tumors with monosomy 3 (M3) or 8q gain increased with increasing pigmentation (31%, 46%, 62%, and 70% having M3 [ < 0.001], and 19%, 43%, 61%, and 63% having 8q gain [ < 0.001] in the 4 increasing pigment groups, respectively). BRCA-associated protein 1 BAP1) loss (known for 204 cases) was associated with increased tumor pigmentation ( = 0.001). Cox regression analysis on survival showed that when chromosome status and pigmentation were both included, pigmentation was not an independent prognostic indicator. Preferentially expressed antigen in melanoma (PRAME) expression was a significant prognostic marker in light tumors ( = 0.02) but not in dark tumors ( = 0.85).

Conclusions: Patients with moderately and heavily pigmented tumors showed a significantly higher UM-related mortality than patients with unpigmented and light tumors ( < 0.001), supporting prior reports on the relation between increased tumor pigmentation and a worse prognosis. Although we previously showed that a dark eye color was associated with tumor pigmentation, we now show that the tumor's genetic status (chromosome 3 and 8q/BAP1 status) is also related to tumor pigmentation. When pigmentation and chromosome 3 status are both included in a Cox regression analysis, pigmentation is not an independent prognostic factor. However, evidence from this and previous studies shows that chromosome changes and PRAME expression have a stronger association with survival when they occur in light tumors than in dark ones. : Proprietary or commercial disclosure may be found after the references.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182323PMC
http://dx.doi.org/10.1016/j.xops.2023.100297DOI Listing

Publication Analysis

Top Keywords

tumor pigmentation
16
uveal melanoma
8
pigmentation prognostic
8
pigmented tumors
8
pigmentation
6
tumor
5
increased histological
4
histological tumor
4
pigmentation uveal
4
melanoma eye
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: