Is to suggest the method of ricin determination in biological liquids during forensic medical and chemicotoxicological examination. This research describes the optimal conditions of sample processing of biological liquids, allowing to extract the components (ricinine and ricinoleic acid) of castor seeds. The recommended analysis conditions allow to perform research for 15 minutes by high resolution mass spectrometry method combined with high-value liquid chromatography on a chromato-mass spectrometer to detect ricinine and ricinoleic acid. The chromatographic (retention time) and mass-spectrometric parameters (mass spectra) were established for the exact high-quality determination of ricinine and ricinoleic acid.
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Is to suggest the method of ricin determination in biological liquids during forensic medical and chemicotoxicological examination. This research describes the optimal conditions of sample processing of biological liquids, allowing to extract the components (ricinine and ricinoleic acid) of castor seeds. The recommended analysis conditions allow to perform research for 15 minutes by high resolution mass spectrometry method combined with high-value liquid chromatography on a chromato-mass spectrometer to detect ricinine and ricinoleic acid.
View Article and Find Full Text PDFRicinus communis L. fruit extract inhibits migration/invasion, induces apoptosis in breast cancer cells and arrests tumor progression in vivo.
Sci Rep
October 2019
Cellular, Molecular and Environmental Biotechnology Laboratory, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, 784028, Assam, India.
Article Synopsis
- Medicinal plant-based therapies, like Ricinus communis L. (castor plant) fruit extract (RCFE), show promise for cancer treatment due to their effectiveness, affordability, and minimal side effects.
- RCFE exhibits strong anti-cancer properties, inducing cytotoxicity and apoptosis in breast cancer cells (MCF-7 and MDA-MB-231) while inhibiting their metastasis and reducing tumor volume in mice.
- Analysis reveals four active compounds in RCFE that contribute to its anti-cancer effects, suggesting its potential as a viable treatment option for breast cancer.
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