Identification of four novel HLA-DQ alleles, HLA-DQA1*01:106, -DQA1*01:107, -DQA1*05:74 and -DQB1*05:01:48.

HLA

Histocompatibility and Immunogenetics Laboratory, Alberta Precision Laboratories, Calgary, Alberta, Canada.

Published: August 2023

AI Article Synopsis

  • The study identifies and characterizes three new alleles of HLA-DQA1 that have non-synonymous mutations, which alter protein function.
  • One new allele of HLA-DQB1 is also characterized, featuring synonymous mutations that do not change the amino acid sequence.
  • This research enhances our understanding of genetic diversity in these important immune system genes.

Article Abstract

Characterization of new alleles, three HLA-DQA1 and one HLA-DQB1, bearing non-synonymous and synonymous mutations, respectively.

Download full-text PDF

Source
http://dx.doi.org/10.1111/tan.15076DOI Listing

Publication Analysis

Top Keywords

identification novel
4
novel hla-dq
4
hla-dq alleles
4
alleles hla-dqa1*01106
4
hla-dqa1*01106 -dqa1*01107
4
-dqa1*01107 -dqa1*0574
4
-dqa1*0574 -dqb1*050148
4
-dqb1*050148 characterization
4
characterization alleles
4
alleles three
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!