AI Article Synopsis
- The study found that damage to RNA from oxidation is linked to aging and higher chances of dying, especially in people with type 2 diabetes.
- Researchers looked at over 6,600 people in total, including those with and without diabetes.
- Unlike RNA damage, damage to DNA from oxidation did not predict death, showing that RNA is more important for understanding aging and health issues.
Article Abstract
Modifications of nucleic acids (DNA and RNA) from oxidative stress is a potential driver of aging per se and of mortality in age-associated medical disorders such as type 2 diabetes (T2D). In a human cohort, we found a strong prediction of all-cause mortality by a marker of systemic oxidation of RNA in patients with T2D (n = 2672) and in nondiabetic control subjects (n = 4079). The finding persisted after the adjustment of established modifiers of oxidative stress (including BMI, smoking, and glycated hemoglobin). In contrast, systemic levels of DNA damage from oxidation, which traditionally has been causally linked to both T2D and aging, failed to predict mortality. Strikingly, these findings were subsequently replicated in an independent general population study (n = 3649). The data demonstrate a specific importance of RNA damage from oxidation in T2D and general aging.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265158 | PMC |
| http://dx.doi.org/10.1111/acel.13839 | DOI Listing |
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