AI Article Synopsis
- Post-COVID-19 syndrome (PCS) fatigue is most severe within the first six months after infection, with differences observed in brain structure and function between patients under and over this timeframe.
- An exploratory study used MRI and PET imaging to compare brain volumes and metabolism in COVID-19 survivors less than six months post-infection (N=18) versus those over six months (N=15).
- Results indicated that patients over six months had smaller brain volumes in areas related to fatigue, while both groups showed altered brain metabolism when compared to healthy individuals, suggesting chronic effects of PCS on brain structure but not metabolism.
Article Abstract
Post-COVID-19 syndrome (PCS) fatigue is typically most severe <6 months post-infection. Combining magnetic resonance imaging (MRI) and positron emission tomography (PET) imaging with the glucose analog [F]-Fluorodeoxyglucose (FDG) provides a comprehensive overview of the effects of PCS on regional brain volumes and metabolism, respectively. The primary purpose of this exploratory study was to investigate differences in MRI/PET outcomes between people < 6 months (N = 18, 11 female) and > 6 months (N = 15, 6 female) after COVID-19. The secondary purpose was to assess if any differences in MRI/PET outcomes were associated with fatigue symptoms. Subjects > 6 months showed smaller volumes in the putamen, pallidum, and thalamus compared to subjects < 6 months. In subjects > 6 months, fatigued subjects had smaller volumes in frontal areas compared to non-fatigued subjects. Moreover, worse fatigue was associated with smaller volumes in several frontal areas in subjects > 6 months. The results revealed no brain metabolism differences between subjects > 6 and < 6 months. However, both groups exhibited both regional hypo- and hypermetabolism compared to a normative database. These results suggest that PCS may alter regional brain volumes but not metabolism in people > 6 months, particularly those experiencing fatigue symptoms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136956 | PMC |
| http://dx.doi.org/10.3390/brainsci13040675 | DOI Listing |
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