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Theranostics of Primary Prostate Cancer: Beyond PSMA and GRP-R. | LitMetric
Unlabelled : The imaging of Prostate-Specific Membrane Antigen (PSMA) is now widely used at the initial staging of prostate cancers in patients with a high metastatic risk. However, its ability to detect low-grade tumor lesions is not optimal.Methods : First, we prospectively performed neurotensin receptor-1 (NTS) IHC in a series of patients receiving both [Ga]Ga-PSMA-617 and [Ga]Ga-RM2 before prostatectomy. In this series, PSMA and GRP-R IHC were also available (n = 16). Next, we aimed at confirming the PSMA/GRP-R/NTS expression profile by retrospective autoradiography (n = 46) using a specific radiopharmaceuticals study and also aimed to decipher the expression of less-investigated targets such as NTS, SST and CXCR4.Results : In the IHC study, all samples with negative PSMA staining (two patients with ISUP 2 and one with ISUP 3) were strongly positive for NTS staining. No samples were negative for all three stains-for PSMA, GRP-R or NTS. In the autoradiography study, binding of [In]In-PSMA-617 was high in all ISUP groups. However, some samples did not bind or bound weakly to [In]In-PSMA-617 (9%). In these cases, binding of [n]In-JMV 6659 and [In]In-JMV 7488 towards NTS and NTS was high.Conclusions : Targeting PSMA and NTS/NTS could allow for the detection of all intraprostatic lesions.
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