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Differential Expression of miRNAs Contributes to Tumor Aggressiveness and Racial Disparity in African American Men with Prostate Cancer. | LitMetric

AI Article Synopsis

  • Prostate cancer is the most common cancer among men in the US and has a higher incidence and mortality rate in African American men compared to European American men.
  • The study investigates the role of microRNAs (miRNAs) in prostate cancer, especially in relation to tumor aggressiveness and racial disparities.
  • Findings reveal specific downregulated miRNAs in African American prostate cancer tissues that may contribute to tumor behavior by negatively regulating the androgen receptor, offering new insights into these disparities.

Article Abstract

Prostate cancer is the leading cancer in incidence and second leading cause of cancer mortality in US men. African American men have significantly higher incidence and mortality rates from prostate cancer than European American men. Previous studies reported that the disparity in prostate cancer survival or mortality can be explained by different biological backgrounds. microRNAs (miRNAs) regulate gene expression of their cognate mRNAs in many cancers. Therefore, miRNAs may be a potentially promising diagnostic tool. The role of miRNAs in prostate cancer aggressiveness and racial disparity has not been fully established. The goal of this study is to identify miRNAs associated with aggressiveness and racial disparity in prostate cancer. Here we report miRNAs that are associated with tumor status and aggressiveness in prostate cancer using a profiling approach. Further, downregulated miRNAs in African American tissues were confirmed by qRT-PCR. These miRNAs have also been shown to negatively regulate the expression of the androgen receptor in prostate cancer cells. This report provides a novel insight into understanding tumor aggressiveness and racial disparities of prostate cancer.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136561PMC
http://dx.doi.org/10.3390/cancers15082331DOI Listing

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