AI Article Synopsis
- C3 glomerulopathies (C3GN) are rare kidney diseases caused by problems with the complement system, leading to C3 accumulation in kidneys; this study analyzed biopsy samples from 332 patients diagnosed with C3GN.
- Among the examined cases, 111 were identified as C3GN, 17 as dense deposit disease (DDD), and the majority (204) were non-classified due to insufficient severity of lesions.
- The findings emphasize the importance of using electron microscopy to assess suspected C3 glomerulopathies, especially in cases where lesions are difficult to detect with other microscopy methods.
Article Abstract
Background: C3 glomerulopathies (C3GN) are a group of rare kidney diseases associated with impaired complement regulation. The effects of this disease include the accumulation of complement C3 in the kidneys. Based on the clinical data, as well as light, fluorescence, and electron microscopy results, the diagnoses were verified. The study group consisted of biopsy specimens, which were obtained from 332 patients who were diagnosed with C3 glomerulopathy. In all cases, histopathological examinations were performed; deposits of complement C3 and C1q components, as well as the immunoglobulins IgA, IgG, and IgM, were identified using immunofluorescence. Furthermore, electron microscopy was also performed.
Results: The histopathological examination results presented cases of C3GN (n = 111) and dense deposit disease (DDD; n = 17). The non-classified (NC) group was the most numerous (n = 204). The lack of classification was due to the poor severity of the lesions, even on the electron microscopic examination or in the presence of intense sclerotic lesions.
Conclusions: In cases of suspected C3 glomerulopathies, we believe an electron microscopy examination is necessary. This examination is beneficial in mild-to-extremely-severe cases of this glomerulopathy, where the lesions are barely discernible when using immunofluorescence microscopy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135645 | PMC |
| http://dx.doi.org/10.3390/biomedicines11041101 | DOI Listing |
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