Neutropenic Enterocolitis: An Uncommon, but Fearsome Complication of Leukemia.

J Hematol

Division of Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.

Published: April 2023

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Article Abstract

Neutropenic enterocolitis (NEC) is a life-threatening condition occurring in severely neutropenic patients, following intensive chemotherapy for leukemia. Its pathogenesis is not entirely understood and believed to be multifactorial, including mucosal injury as a result of cytotoxic drugs, profound neutropenia, impaired host defense and possibly microbiota changes. Establishing an early diagnosis is key. The management of NEC remains undefined due to lack of high-quality clinical data. With a better understanding of the disease, a more conservative approach is preferred over surgical intervention. The involvement of a multi-disciplinary team, consisting of the oncologist, infectious diseases specialists and surgeons is highly recommended. This review aims to delineate insights into the pathophysiology and clinical presentation of NEC and to emphasize the diagnostic and therapeutic approach to this condition.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181327PMC
http://dx.doi.org/10.14740/jh1105DOI Listing

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