Lia et al. [1] discovered the critical role of STIM1 ER Ca sensor in the functional decline of astrocytes in the AD-like pathology in PS2APP mice. Profound downregulation of STIM1 expression in astrocytes in the disease results in the decreased ER Ca content and severely impaired evoked as well as spontaneous astrocytic Ca signalling. Aberrant astrocytic Ca signalling translated into impaired synaptic plasticity and memory. Astrocyte-specific overexpression of STIM1 restored Ca excitability and rectified synaptic and memory deficits.
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| http://dx.doi.org/10.1016/j.ceca.2023.102756 | DOI Listing |
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