Site-Selective C-H Functionalization of Carbazoles.

Angew Chem Int Ed Engl

Department of Chemistry and Biochemistry, Texas Tech University, USA.

Published: June 2023

Carbazole alkaloids hold great potential in pharmaceutical and material sciences. However, the current approaches for C1 functionalization of carbazoles rely on the use of a pre-installed directing group, severely limiting their applicability and hindering their overall efficiency. Herein, we report for the first time the development of direct Pd-catalyzed C-H alkylation and acylation of carbazoles assisted by norbornene (NBE) as a transient directing mediator. Notably, the involvement of a six-membered palladacycle intermediate was suggested in this case, representing the first example of such intermediacy within the extensively studied Pd/norbornene reactions realm.

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Source
http://dx.doi.org/10.1002/anie.202303110DOI Listing

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