Super-resolving the coarse outputs of global climate simulations, termed downscaling, is crucial in making political and social decisions on systems requiring long-term climate change projections. Existing fast super-resolution techniques, however, have yet to preserve the spatially correlated nature of climatological data, which is particularly important when we address systems with spatial expanse, such as the development of transportation infrastructure. Herein, we show an adversarial network-based machine learning enables us to correctly reconstruct the inter-regional spatial correlations in downscaling with high magnification of up to 50 while maintaining pixel-wise statistical consistency. Direct comparison with the measured meteorological data of temperature and precipitation distributions reveals that integrating climatologically important physical information improves the downscaling performance, which prompts us to call this approach [Formula: see text]SRGAN (Physics Informed Super-Resolution Generative Adversarial Network). The proposed method has a potential application to the inter-regionally consistent assessment of the climate change impact. Additionally, we present the outcomes of another variant of the deep generative model-based downscaling approach in which the low-resolution precipitation field is substituted with the pressure field, referred to as [Formula: see text]SRGAN (Precipitation Source Inaccessible SRGAN). Remarkably, this method demonstrates unexpectedly good downscaling performance for the precipitation field.
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http://dx.doi.org/10.1038/s41598-023-32947-0 | DOI Listing |
Invest Ophthalmol Vis Sci
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Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Purpose: This study aimed to identify a novel recombinant adeno-associated virus (rAAV) capsid variant that can widely transfect the deep retina through intravitreal injection and to assess their effectiveness and safety in gene delivery.
Methods: By adopting the sequences of various cell-penetrating peptides and inserting them into the capsid modification region of AAV2, we generated several novel variants. The green fluorescent protein (GFP)-carrying variants were screened following intravitreal injection.
Cerebellum
January 2025
Department of Neuroscience, University of Mons, Mons, Belgium.
As brain-machine interfaces (BMI) are growingly used in clinical settings, understanding how to apply brain stimulation is increasingly important. Despite the emergence of optogenetic techniques, ethical and medical concerns suggest that interventions that are safe and non-invasive, such as Transcranial Alternating Current Stimulation (tACS), are more likely to be employed in human in the near future. Consequently, the question of how and where to apply current stimulation is becoming increasingly important for the efficient neuromodulation of both neurological and psychiatric disorders.
View Article and Find Full Text PDFSoft Matter
January 2025
Department of Mechanical and Aerospace Engineering, University at Buffalo, Buffalo, NY 14260, USA.
Monolayer assembly of charged colloidal particles at liquid interfaces opens a new avenue for advancing the additive manufacturing of thin film materials and devices with tailored properties. In this study, we investigated the dynamics of electrosprayed colloidal particles at curved droplet interfaces through a combination of physics-based computational simulations and machine learning. We employed a novel mesh-constrained Brownian dynamics (BD) algorithm coupled with Ansys® electric field simulations to model the transport and assembly of charged particles on a non-spherical droplet surface.
View Article and Find Full Text PDFEur J Breast Health
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Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, USA.
Breast cancer is the most common cancer type among women worldwide with an average lifetime risk of 12.9%. Early detection and screening are the most important factors for improved prognosis and mammography remains the main screening tool for the average risk patients.
View Article and Find Full Text PDFJ Genet
January 2025
Programa de Pos-graduacao em Ciencias Biologicas (Genetica), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
A significant proportion of next-generation sequencing (NGS) data ends up not being used since they comprise information out-of-scope of the primary studies. This 'waste' of potential can be harnessed to explore organellar genomes, such as the mitochondrial DNA, and be used for evolutionary, conservation and biodiversity research. We present the complete mitochondrial genomes of the deep-sea methanotrophic sponges and (Demospongiae, Poecilosclerida) retrieved from previously published whole metagenome sequencing data.
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