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Challenges in the treatment of cutaneous leishmaniasis caused by in four travelers: a case series.

Ther Adv Infect Dis

November 2024

Department of Infectious Diseases at Mount Sinai Morningside/West, New York, NY, USA.

We describe a group of four travelers returning to the United States and Canada who acquired infection in the Peruvian Amazon. Pentavalent antimonials are the preferred treatment option for cutaneous leishmaniasis (CL) in most endemic countries in Central and South America. However, we initially treated our patients with liposomal amphotericin B (LAB) and miltefosine since these are the only two available Food and Drug Administration approved drugs in the United States.

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First case of urban leishmaniasis in the Campeche State, Mexico.

Rev Inst Med Trop Sao Paulo

October 2024

Universidad Autónoma de Campeche, Centro de Investigaciones Biomédicas, Laboratorio de Enfermedades Transmitidas por Vectores y Zoonosis, Campeche, Campeche, Mexico.

Article Synopsis
  • Cutaneous leishmaniasis accounts for 99% of leishmaniasis cases in Mexico and typically affects people in rural areas, but a case in Campeche State marks a first for urban transmission.* -
  • A 75-year-old man was misdiagnosed with a bacterial infection before a skin lesion on his ear was identified as leishmaniasis, confirmed through tissue testing that detected Leishmania amastigotes.* -
  • The case highlights the need for awareness of leishmaniasis in urban settings and signals a shift in understanding its transmission in non-endemic areas of Mexico.*
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Article Synopsis
  • - Cutaneous leishmaniasis (CL) is a neglected tropical disease with very few cases reported in Côte d'Ivoire since its identification in 1967, highlighting a significant gap in awareness and diagnosis.
  • - A recent case involved a 15-year-old male with skin lesions and accompanying symptoms, which was confirmed as CL through a biopsy, but he sadly passed away before treatment could be administered.
  • - The rarity of CL in Côte d'Ivoire leads to low awareness among healthcare professionals, necessitating urgent strategies for better education on diagnosis and treatment, along with the need for improved epidemiological data.
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Background: Cutaneous leishmaniasis is endemic in Iran.

Objective: We sought to investigate the therapeutic outcomes and complications of treatment in patients with cutaneous leishmaniasis.

Methods: This case series enrolled patients with smear-proven cutaneous leishmaniasis who visited our center in Iran from 2018 to 2019.

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In 2022, the Pan American Health Organization recommended the intralesional application (IL) of pentavalent antimonials in adult patients with localized cutaneous leishmaniasis (CL) caused by Leishmania (Viannia) braziliensis. Other guidelines differ from that recommendation, considering that infections caused by a Leishmania species that can be associated with increased risk for mucosal leishmaniasis, in particular L. (V.

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