Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1136/archdischild-2022-325061 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hydrogel loaded with cerium-manganese nanoparticles and nerve growth factor enhances spinal cord injury repair by modulating immune microenvironment and promoting neuronal regeneration.
J Nanobiotechnology
January 2025
Department of Orthopedics, Huashan Hospital, Fudan University, No. 12, Middle Wulumuqi Road, Jing'an District, Shanghai, 200040, China.
Background: Spinal cord injury (SCI) treatment remains a formidable challenge, as current therapeutic approaches provide only marginal relief and fail to reverse the underlying tissue damage. This study aims to develop a novel composite material combining enzymatic nanoparticles and nerve growth factor (NGF) to modulate the immune microenvironment and enhance SCI repair.
Methods: CeMn nanoparticles (NP) and CeMn NP-polyethylene glycol (PEG) nanozymes were synthesized via sol-gel reaction and DSPE-mPEG modification.
Biomechanical comparison of the efficacy of Cfr-PEEK and titanium systems in the fixation following sagittal split advancement osteotomy: a biomechanical study.
BMC Oral Health
January 2025
Department of Oral and Maxillofacial Surgery, Ordu University, Cumhuriyet Yerleşkesi Cumhuriyet Mahallesi, 52200, Ordu, Türkiye, Turkey.
Background: This study evaluates the efficacy of carbon fiber reinforced Polyetheretherketone (Cfr-PEEK) in fixation after sagittal split ramus osteotomy (SSRO) by comparing it with titanium in vitro.
Methods: Twenty-eight sheep hemimandibles were randomly assigned to four groups for SSRO surgery. Fixation was performed with a 4-hole titanium mini plate for 5 mm advancement in Group 1, with a 4-hole Cfr-PEEK mini plate for 5 mm advancement for Group 2, with a 4-hole titanium mini plate for 10 mm advancement for Group 3, and with a 4-hole Cfr-PEEK mini plate for 10 mm advancement for Group 4.
A high-valence bismuth(V) nanoplatform triggers cancer cell death and anti-tumor immune responses with exogenous excitation-free endogenous HO- and O-independent ROS generation.
Nat Commun
January 2025
State Key Lab of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University 800 Dongchuan Road, Shanghai, P. R. China.
Reactive oxygen species with evoked immunotherapy holds tremendous promise for cancer treatment but has limitations due to its dependence on exogenous excitation and/or endogenous HO and O. Here we report a versatile oxidizing pentavalent bismuth(V) nanoplatform (NaBiO-PEG) can generate reactive oxygen species in an excitation-free and HO- and O-independent manner. Upon exposure to the tumor microenvironment, NaBiO-PEG undergoes continuous H-accelerated hydrolysis with •OH and O generation through electron transfer-mediated Bi-to-Bi conversion and lattice oxygen transformation.
View Article and Find Full Text PDFCellulases Production by Aspergillus unguis in Solid State Fermentation and Enzymatic Hydrolysis of Dilute Acid-Treated Groundnut Fodder.
Curr Microbiol
January 2025
Department of Botany, Mahatma Gandhi Central University, Motihari, Bihar, 845401, India.
Groundnut fodder was utilized as a bioresource for the production of cellulases through solid state fermentation (SSF). Aspergillus unguis was initially grown on modified groundnut fodder for cellulase production and the fodder was hydrolyzed by the crude cellulase extract into fermentable hydrolyzate. The highest titer of Filter paperase (FPase), Carboxymethyl cellulase (CMCase), β-glucosidase, and protein content were found to be 11.
View Article and Find Full Text PDFProtecting monoclonal antibodies via competitive interfacial adsorption of nonionic surfactants.
J Colloid Interface Sci
December 2024
Biological Physics Laboratory, Department of Physics and Astronomy, University of Manchester, Oxford Road, Schuster Building, Manchester M13 9PL, UK. Electronic address:
Hypothesis: Bioengineered monoclonal antibodies (mAbs) have gained significant recognition as medical therapies. However, during processing, storage and use, mAbs are susceptible to interfacial adsorption and desorption, leading to structural deformation and aggregation, and undermining their bioactivity. To suppress antibody surface adsorption, nonionic surfactants are commonly used in formulation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!