AI Article Synopsis
- CDKL5 deficiency disorder (CDD) causes early-onset epilepsy along with lifelong cognitive and motor challenges, highlighting the need for effective communication assessment tools.
- The study assessed the Communication and Symbolic Behavior Scales-Developmental Profile Infant Toddler Checklist (CSBS-DP ITC) with 150 caregivers, revealing a "floor effect," where many participants scored low, limiting the tool's effectiveness.
- While test-retest reliability was excellent, the poor performance on the three-factor model suggests that the CSBS-DP ITC may not be sensitive enough to track changes in communication for clinical trials involving CDD.
Article Abstract
CDKL5 deficiency disorder (CDD) results in early-onset epilepsy and lifelong cognitive and motor impairments. With no validated measure for communication in CDD, this study evaluated the psychometric properties of the Communication and Symbolic Behavior Scales-Developmental Profile Infant Toddler Checklist (CSBS-DP ITC). Caregivers (n = 150; affected individuals aged 1-29 years) completed the CSBS-DP ITC. Distribution of scores indicated a floor effect. There was poor divergent validity for the three-factor model but goodness of fit and convergent validity data were satisfactory for the one-factor model. Individuals with poorer overall functional abilities scored lower on the CSBS-DP ITC. Test-retest reliability was excellent. The floor effect could explain the very high reliability, suggesting problems as a sensitive outcome measure in clinical trials for CDD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10699574 | PMC |
| http://dx.doi.org/10.1007/s10803-023-06002-w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!