AI Article Synopsis
- - Previous studies suggested a link between periodontitis (PD) and migraines, but the relationship was uncertain; this research used Mendelian randomization (MR) to clarify if one causes the other.
- - The study analyzed data from a large population, including 17,353 PD cases and over 360,000 migraine controls, using genetic markers to assess causality.
- - Results showed no significant causal relationship between PD and migraines, indicating that neither condition influences the other in the population studied.
Article Abstract
Introduction: Previous observational studies have associated periodontitis (PD) with migraine; however, the results are inconclusive and the causality of the association between PD and migraine remains unclear. This two-sample Mendelian randomization (MR) study was performed to explore the bi-directional causal relationship between PD and migraine.
Methods: To investigate the relationship between PD (17,353 cases; 28,210 controls) and migraine (1072 cases; 360,122 controls), we used genetic tools from the largest available genome-wide association study of European descent. Inverse variance-weighted (IVW) and a series of sensitivity analyses were used to explore the association between migraine and PD. We performed an MR study using seven SNPs (single nucleotide polymorphisms) as instrumental variables for PD to investigate the causal relationship between migraine and PD.
Results: We found no significant causal relationship between PD and migraine (odds ratio, OR = 1.000; 95% confidence interval, CI = 0.99-1.00; p = 0.65). Similarly, no evidence supported a causal relationship between migraine and PD (OR = 0.07; CI = 2.04 × 10-2.65 × 10; p = 0.77). A sensitivity analysis revealed that no potential polymorphic effect (p = 0.356) and heterogeneity (p = 0.652) exists for the variants used in constructing the genetic instrument.
Conclusions: Based on the results of our MR study, there is no causal relationship between PD and migraines or migraines and PD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310615 | PMC |
| http://dx.doi.org/10.1007/s40120-023-00484-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pathogenicity and drug resistance characterization of Streptococcus agalactiae isolated from dairy cows.
Pol J Vet Sci
December 2024
Department of Customs Inspection and Quarantine, Shanghai Customs College, Shanghai, China.
, commonly known as , is a critical zoonotic pathogen that significantly reduces milk yield and product quality and poses a significant risk to public health. Although is increasingly recognised as a principal agent causing milkborne infections, research dedicated to this pathogen in dairy cattle has been less extensive than that of other pathogens. This study aimed to examine the antibiotic resistance profiles of derived from dairy cows and assess its pathogenicity using validated in vivo models.
View Article and Find Full Text PDFEffect of commercial prescription diets containing prebiotics on clinical signs and fecal microbiome in dogs with intestinal disease.
Pol J Vet Sci
December 2024
School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan.
Diet has emerged as a key modulator of the gut microbiota, offering a potential strategy for disease prevention and management. This study investigated the effects of the Prescription Diet Gastrointestinal Biome (GB) on 7 healthy dogs and 16 dogs with chronic gastrointestinal diseases (GI dogs). Our investigation monitored changes in body weight and the Canine Inflammatory Bowel Disease Activity Index (CIBDAI) in 16 GI dogs fed a GB diet.
View Article and Find Full Text PDFCircadian Disruption in Glaucoma: Causes, Consequences, and Countermeasures.
Front Biosci (Landmark Ed)
December 2024
Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN 55455, USA.
This review explores the intricate relationship between glaucoma and circadian rhythm disturbances. As a principal organ for photic signal reception and transduction, the eye plays a pivotal role in coordinating the body's circadian rhythms through specialized retinal ganglion cells (RGCs), particularly intrinsically photosensitive RGCs (ipRGCs). These cells are critical in transmitting light signals to the suprachiasmatic nucleus (SCN), the central circadian clock that synchronizes physiological processes to the 24-hour light-dark cycle.
View Article and Find Full Text PDFMachine Learning Reveals Aneuploidy Characteristics in Cancers: The Impact of BEX4.
Front Biosci (Landmark Ed)
November 2024
Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, 230022 Hefei, Anhui, China.
Background: Aneuploidy is crucial yet under-explored in cancer pathogenesis. Specifically, the involvement of brain expressed X-linked gene 4 () in microtubule formation has been identified as a potential aneuploidy mechanism. Nevertheless, 's comprehensive impact on aneuploidy incidence across different cancer types remains unexplored.
View Article and Find Full Text PDFInvestigating a new alarming outbreak of in Tuscany (Central Italy): molecular characterization and gene typing elucidate the complex phytoplasma ecology in the vineyard agroecosystem.
Front Plant Sci
December 2024
Department of Agriculture, Food and Environment, University of Pisa, Pisa, Italy.
(FD) is a major grapevine disease in Europe, despite the quarantine status of its causal agent [FD phytoplasma (FDp)] and the mandatory monitoring and vector control practices. As alarming FD epidemic outbreaks continue to appear in Tuscany (Central Italy), a 4-year survey was carried out in the main wine-growing areas of the region, where FD presence was investigated in both primary and secondary FDp hosts and vectors, i.e.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!