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| http://dx.doi.org/10.37201/req/001.2023 | DOI Listing |
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Gut microbiota changes associated with frailty in older adults: A systematic review of observational studies.
World J Clin Cases
December 2024
College of Nursing and Health Management, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China.
Background: Frailty is a complex aging-related syndrome characterized by a cumulative loss of physiological reserve and increased vulnerability to adverse clinical outcomes, including falls, disability, incapacity and death. While an increasing number of studies suggest that the gut microbiota may play a key role in the pathophysiology of frailty, direct evaluation of the association between gut microbiome alterations and frailty in older adults remains limited.
Aim: To gain insight into gut dysbiosis in frail older adults.
Microbial spectrum and resistance of odontogenic abscesses - microbiological analysis using next generation sequencing.
Clin Oral Investig
December 2024
Department of Oral and Maxillofacial Plastic Surgery, University Medical Center of the University Bonn, Venusberg Campus 1, Building 11, 2. OG, D-53127, Bonn, Germany.
Objectives: This study aimed to map the microbiome of odontogenic abscesses using next-generation sequencing (NGS) to identify bacterial and fungal species, as well as antibiotic resistances.
Materials And Methods: Wound swabs were taken from patients treated for odontogenic abscesses at the Department of Oral and Maxillofacial Plastic Surgery, University Hospital Bonn. NGS was used to analyze the swabs, and bioinformatic analysis assigned the genetic material to microorganism profiles and identified antibiotic resistances.
Signatures of lower respiratory tract microbiome in children with severe community-acquired pneumonia using shotgun metagenomic sequencing.
J Microbiol Immunol Infect
November 2024
Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:
Background: Severe community-acquired pneumonia was associated with high morbidity and mortality in children. However, species-level microbiome of lower airway was sparse, and we used shotgun metagenomic next-generation sequencing to explore microbial signatures.
Methods: We conducted a prospective cohort study to recruit children under 18 who required admission to an intensive care unit for community-acquired pneumonia between December 2019 and February 2022.
Transcriptional delineation of polysaccharide utilization loci in the human gut commensal DSM18205 and co-culture with exemplar species on dietary plant glycans.
Appl Environ Microbiol
December 2024
Michael Smith Laboratories, The University of British Columbia, Vancouver, British Columbia, Canada.
Unlabelled: There is growing interest in members of the genus (family ) as members of a well-balanced human gut microbiota (HGM). are particularly associated with the consumption of a diet rich in plant polysaccharides comprising dietary fiber. However, understanding of the molecular basis of complex carbohydrate utilization in species is currently incomplete.
View Article and Find Full Text PDFOmic characterizing and targeting gut dysbiosis in children with autism spectrum disorder: symptom alleviation through combined probiotic and medium-carbohydrate diet intervention - a pilot study.
Gut Microbes
December 2024
Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.
Article Synopsis
- Autism spectrum disorder (ASD) currently has no effective diagnostic or treatment methods, but disruptions in gut microbiota have been linked to ASD, leading to research into probiotics and dietary changes as potential therapies.
- A study compared the gut microbiomes of children with ASD to typically developing children, identifying unique dysbiosis patterns and assessing the impact of a combined probiotic (Probio-M8) and medium-carbohydrate diet over three months.
- Results indicated that the intervention significantly improved autism symptoms and gastrointestinal health, with corresponding positive changes in gut bacteria and associated metabolites, suggesting that this approach could be a valuable addition to ASD treatment options.
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