AI Article Synopsis
- Radiotherapy is a key treatment for brain metastases, with advancements allowing patients to live longer and focus on reducing treatment side effects and enhancing quality of life.
- Historically, whole-brain radiation therapy (WBRT) was the standard, but new methods like hippocampal sparing WBRT and stereotactic radiosurgery (SRS) show promise.
- Recent discussions include techniques that protect critical brain structures for better neurocognitive outcomes, the benefits of preoperative and fractionated-SRS, and strategies to manage issues like radiation necrosis.
Article Abstract
Radiotherapy remains a cornerstone treatment of brain metastases. With new treatment advances, patients with brain metastases are living longer, and finding solutions for mitigating treatment-related neurotoxicity and improving quality of life is important. Historically, whole-brain radiation therapy (WBRT) was widely used but treatment options such as hippocampal sparing WBRT and stereotactic radiosurgery (SRS) have emerged as promising alternatives. Herein, we discuss the recent advances in radiotherapy for brain metastases including the sparing of critical structures that may improve long-term neurocognitive outcomes (eg, hippocampus, fornix) that may improve long-term neurocognitive outcome, evidence supporting preoperative and fractionated-SRS, and treatment strategies for managing radiation necrosis.
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| http://dx.doi.org/10.1016/j.soc.2023.02.007 | DOI Listing |
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