AI Article Synopsis
- Hydrogel adhesives that quickly stick to bleeding tissues while being safe for the body are important for stopping bleeding efficiently.
- A new flexible hydrogel made from dopamine-conjugated hyaluronic acid is created using light to harden the material, giving it strong adhesion and rapid gelation.
- This hydrogel shows excellent performance in stopping bleeding in various animal models, outperforming traditional products and demonstrating good compatibility with living tissue and low inflammation.
Article Abstract
Hydrogel adhesives integrating both rapid and strong adhesion to blooding tissues and biocompatibility are highly desired for fast hemostasis. Herein, a flexible hyaluronic acid hydrogel adhesive is fabricated via photocrosslinking of the solution originating from dopamine-conjugated maleic hyaluronic acid (DMHA) in situ. The introduction of acrylate groups with high substitutions into the hydrogel matrix endows the adhesive with rapid gelation and strong tissue adhesion properties through photopolymerization. Moreover, the high substitution of catechol groups with unoxidized state can not only induce red blood cell aggregation and platelets adhesion but also adhere to wound tissue to further enhance hemostasis. Based on its bio-adhesion and procoagulant activity, the DMHA hydrogel formed in situ reveals superior hemostatic performance in the rat liver injury model and noncompressible hemorrhage model, and rabbit femoral artery puncture model, compared to commercial products (gauze, absorbable gelatin sponge) and oxidized DMHA (SMHA) hydrogel. Besides, the hydrogel exhibited good adaptability, biodegradability, and superior cytocompatibility as well as negligible inflammation. This hydrogel adhesive is a promising biological adhesive for hemorrhage control.
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| http://dx.doi.org/10.1016/j.carbpol.2023.120854 | DOI Listing |
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