AI Article Synopsis
- Genes responsible for cell identity are regulated by specific enhancer elements that interact with transcription factors, while housekeeping genes usually don’t engage with distal enhancers.
- The protein Ronin (Thap11) helps gather multiple housekeeping and metabolic gene promoters to regulate their expression, similar to the way enhancers interact with promoters for identity genes.
- This suggests that clustering of regulatory elements is a shared mechanism for both cell identity and housekeeping genes, but different factors are involved in creating these interactions.
Article Abstract
Genes that are key to cell identity are generally regulated by cell-type-specific enhancer elements bound by transcription factors, some of which facilitate looping to distant gene promoters. In contrast, genes that encode housekeeping functions, whose regulation is essential for normal cell metabolism and growth, generally lack interactions with distal enhancers. We find that Ronin (Thap11) assembles multiple promoters of housekeeping and metabolic genes to regulate gene expression. This behavior is analogous to how enhancers are brought together with promoters to regulate cell identity genes. Thus, Ronin-dependent promoter assemblies provide a mechanism to explain why housekeeping genes can forgo distal enhancer elements and why Ronin is important for cellular metabolism and growth control. We propose that clustering of regulatory elements is a mechanism common to cell identity and housekeeping genes but is accomplished by different factors binding distinct control elements to establish enhancer-promoter or promoter-promoter interactions, respectively.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329844 | PMC |
| http://dx.doi.org/10.1016/j.celrep.2023.112505 | DOI Listing |
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