AI Article Synopsis
- Endocarditis is a rare but serious condition that requires careful diagnosis, especially in those with weakened immune systems.
- A 50-year-old man with advanced thymoma and undergoing immunosuppressive treatment experienced worsening breathing issues, leading to the discovery of a mass in his pulmonary artery that turned out to be endocarditis of the pulmonary valve.
- Despite surgery and antifungal treatment, the patient unfortunately passed away, highlighting the challenges of diagnosing and treating endocarditis, especially in immunocompromised patients where timely intervention is crucial.
Article Abstract
Background: endocarditis is a rare cause of infective endocarditis and requires high index of suspicion for diagnosis.
Case Summary: We describe a case of a 50-year-old man with history of metastatic thymoma on immunosuppression (gemcitabine and capecitabine) who presented with progressive dyspnoea. Echocardiography and computed tomography (CT) of chest showed filling defect in the pulmonary artery. The initial differential diagnosis was of pulmonary embolism and metastatic disease. The mass was subsequently excised, which revealed a diagnosis of endocarditis of the pulmonary valve. Unfortunately, he passed away despite medical treatment with antifungal therapy after surgery.
Discussion: endocarditis should be suspected in immunosuppressed hosts with negative blood cultures and large vegetations on echocardiography. Diagnosis is made by tissue histology but may be difficult or delayed. Optimal treatment involves aggressive surgical debridement and prolonged antifungal therapy; prognosis is poor with high mortality.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170530 | PMC |
| http://dx.doi.org/10.1093/ehjcr/ytad218 | DOI Listing |
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