The storage, sharing, and analysis of genomic data poses technical and logistical challenges that have precipitated the development of cloud-based computing platforms designed to facilitate collaboration and maximize the scientific utility of data. To understand cloud platforms' policies and procedures and the implications for different stakeholder groups, in summer 2021, we reviewed publicly available documents (N = 94) sourced from platform websites, scientific literature, and lay media for five NIH-funded cloud platforms (the All of Us Research Hub, NHGRI AnVIL, NHLBI BioData Catalyst, NCI Genomic Data Commons, and the Kids First Data Resource Center) and a pre-existing data sharing mechanism, dbGaP. Platform policies were compared across seven categories of data governance: data submission, data ingestion, user authentication and authorization, data security, data access, auditing, and sanctions. Our analysis finds similarities across the platforms, including reliance on a formal data ingestion process, multiple tiers of data access with varying user authentication and/or authorization requirements, platform and user data security measures, and auditing for inappropriate data use. Platforms differ in how data tiers are organized, as well as the specifics of user authentication and authorization across access tiers. Our analysis maps elements of data governance across emerging NIH-funded cloud platforms and as such provides a key resource for stakeholders seeking to understand and utilize data access and analysis options across platforms and to surface aspects of governance that may require harmonization to achieve the desired interoperability.
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http://dx.doi.org/10.1016/j.xhgg.2023.100196 | DOI Listing |
Child Abuse Negl
January 2025
Social Science Research Institute, Pennsylvania State University, United States of America. Electronic address:
Background: Neonatal abstinence syndrome (NAS), or withdrawal from prenatal opioid exposure at birth, can trigger a referral to child protective services (CPS). However, there is some evidence of selection into NAS diagnosis because NAS screening is not universal. Such referrals may protect the infant, help connect the mother to services, or cause harm.
View Article and Find Full Text PDFAnnu Rev Neurosci
January 2025
Department of Cognitive and Psychological Sciences and Carney Institute for Brain Science, Brown University, Providence, Rhode Island, USA; email:
The twenty-first century has brought forth a deluge of theories and data shedding light on the neural mechanisms of motivated behavior. Much of this progress has focused on dopaminergic dynamics, including their signaling properties (how do they vary with expectations and outcomes?) and their downstream impacts in target regions (how do they affect learning and behavior?). In parallel, the basal ganglia have been elevated from their original implication in motoric function to a canonical circuit facilitating the initiation, invigoration, and selection of actions across levels of abstraction, from motor to cognitive operations.
View Article and Find Full Text PDFAnnu Rev Anal Chem (Palo Alto Calif)
January 2025
2School of Pharmaceutical Sciences, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; email:
Mass spectrometry-based proteomics and metaproteomics have long been used in the study of human microbiomes, with the potential of metaproteomics only recently being fully harnessed. This progress is due to the advancements of high-performance mass spectrometers, innovative proteomics strategies, and the development of dedicated bioinformatics tools. In this review, we critically examine the recent technological developments that enhance the application of metaproteomics in clinical microbiome analysis.
View Article and Find Full Text PDFJ Radiol Prot
January 2025
Department of Biostatistics, Soon Chun Hyang University Hospital Bucheon, Bucheon, Gyeonggi-do, Korea (the Republic of).
This study investigated the additional radiation exposure, influencing factors, and clinical significance of overlapping Z-axis coverage in abdominopelvic CT scans performed consecutively after same-day chest CT scans. Data from 761 patients were analyzed, with measuring the total and overlapping Z-axis coverage of the portal venous phase in abdominopelvic CT scans. The average overlapping portion was 33.
View Article and Find Full Text PDFAnnu Rev Chem Biomol Eng
January 2025
1Department of Chemical & Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, USA; email:
Understanding the molecular, cellular, and physiological components of neurodegenerative diseases (NDs) is paramount for developing accurate diagnostics and efficacious therapies. However, the complexity of ND pathology and the limitations associated with conventional analytical methods undermine research. Fortunately, microfluidic technology can facilitate discoveries through improved biomarker quantification, brain organoid culture, and small animal model manipulation.
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