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| http://dx.doi.org/10.1093/nsr/nwad067 | DOI Listing |
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CBX3 Downregulates HLTF to Activate PI3K/AKT Signaling Promoting Cholangiocarcinoma.
Adv Biol (Weinh)
November 2024
Research Laboratory of Hepatobiliary Tumor, Department of Hepatobiliary Surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, 410005, China.
Cholangiocarcinoma (CCA) is an aggressive cancer with poor response to chemotherapy or radiation, necessitating novel therapeutic approaches. Epigenetic regulation, which is reversible, plays a significant role in cancer progression. CBX3 (HP1γ), a key heterochromatin protein, regulates gene expression by interacting with histone H3 lysine 9 trimethyl (H3K9me3) markers.
View Article and Find Full Text PDFGamma-glutamyl transferase secreted by Helicobacter pylori promotes the development of gastric cancer by affecting the energy metabolism and histone methylation status of gastric epithelial cells.
Cell Commun Signal
August 2024
Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Background: Helicobacter pylori (H. pylori) infection is critical in the development and occurrence of gastric cancer. H.
View Article and Find Full Text PDFTERT upstream promoter methylation regulates TERT expression and acts as a therapeutic target in TERT promoter mutation-negative thyroid cancer.
Cancer Cell Int
August 2024
Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhongshan Second Road, Guangzhou, Guangdong, 510080, China.
Article Synopsis
- - The study investigates the role of DNA methylation in regulating TERT gene expression in thyroid cancer, specifically how methylation affects TERT activity and cellular outcomes in TERT mutation-negative cells.
- - Treatment with DNA demethylating agents like 5-azacytidine and decitabine resulted in decreased TERT expression, increased cell apoptosis, and inhibited growth of thyroid cancer cells with hypermethylated TERT.
- - The research identified that the chromatin remodeling protein CHD4 binds to the methylated TERT promoter, promoting its transcription by modifying histone markers, which influences gene expression dynamics.
Inhibition of DNMT1 attenuates experimental food allergy.
Mol Immunol
September 2024
State Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University and Institute of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China. Electronic address:
Background: The treatment of food allergy (FA) needs improvement. The treatment of immune disorders can be improved by regulating epigenetic marks, which is a promising method. The objective of this research is to alleviate experimental FA by employing an inhibitor of DNA methyltransferase-1 (DNMT1).
View Article and Find Full Text PDFOxidative stress contributes to hypermethylation of Histone H3 lysine 9 in placental trophoblasts from preeclamptic pregnancies.
Front Endocrinol (Lausanne)
May 2024
Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA, United States.
Background And Objective: Aberrant epigenetic regulation and increased oxidative stress in the placenta play a significant role in placental pathophysiology and fetal programming in preeclampsia, a hypertensive disorder in human pregnancy. The purpose of the study is to investigate if hypermethylation of histone H3K9 occurs in placental trophoblasts from preeclampsia.
Methods: Trophoblasts were isolated and cultured from 14 placentas, 7 from normotensive pregnant women and 7 from preeclamptic pregnancies.
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