AI Article Synopsis
- Polypharmacy, or the use of five or more medications, may lead to issues with sticking to prescribed treatments, particularly in women with HIV.
- A study analyzed data from the Women's Interagency HIV Study, focusing on adherence to antiretroviral therapy (ART) and patterns of polypharmacy among 1,538 women aged 18 and older.
- Results showed distinct patterns for adherence and polypharmacy, but the joint analysis found no significant relationship between the two, suggesting a need for further research using more precise measures of adherence.
Article Abstract
Background: Polypharmacy, using five or more medications, may increase the risk of nonadherence to prescribed treatment. We aimed to identify the interrelationship between trajectories of adherence to antiretroviral therapy (ART) and polypharmacy.
Methods: We included women with HIV (aged ≥ 18) enrolled in the Women's Interagency HIV Study in the United States from 2014 to 2019. We used group-based trajectory modeling (GBTM) to identify trajectories of adherence to ART and polypharmacy and the dual GBTM to identify the interrelationship between adherence and polypharmacy.
Results: Overall, 1,538 were eligible (median age of 49 years). GBTM analysis revealed five latent trajectories of adherence with 42% of women grouped in the consistently moderate trajectory. GBTM identified four polypharmacy trajectories with 45% categorized in the consistently low group.
Conclusions: The joint model did not reveal any interrelationship between ART adherence and polypharmacy trajectories. Future research should consider examining the interrelationship between both variables using objective measures of adherence.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182649 | PMC |
| http://dx.doi.org/10.1186/s12981-023-00520-4 | DOI Listing |
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