[Dynamics of protein biosynthesis in a Streptomyces erythreus culture and its alteration as affected by exogenous erythromycin].

The intensity of protein biosynthesis in cultures of Streptomyces erythreus estimated by the specific incorporation of 2[14C]-valine into the mycelium changed in accordance with a definite irregular rhythm. When the samples were collected every 6 hours a number of pronounced radioactivity peaks characterizing the intensity of the label incorporation was observed. The height of the peaks was different and they were recorded at different intervals during both the phase of the culture intensive growth and the stationary phase. Erythromycin added to the fermentation medium inhibited protein synthesis at the stationary phase which was evident of the antibiotic effect on the regulatory apparatus controlling the active mycelium growth.