We report 3 cases of rickettsial hepatitis observed in the Lyon area which were secondary to boutonneuse fever. The temperature was elevated and clinical signs were an often painful hepatomegaly and digestive disorders. These signs are only indicative when accompanied by atypical pneumonopathy or exantherma. Indeed, if the inflammatory syndrome is clear, hepatic function is little perturbed. Diagnosis is sometimes influenced by the epidemiological situation, and depends on serologic tests and histological evidence of granulomatous hepatitis (2 of the 3 cases here). The successful antibiotic treatment shows that patients presenting febrile granulomatous hepatitis should be tested for rickettsiosis.
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Microorganisms
November 2024
Center for Animal Disease Control, University of Miyazaki, Miyazaki 889-2192, Japan.
Spotty liver disease (SLD) affects free-range laying hens, leading to mortality and reduced egg production. species, including , have been associated with SLD cases worldwide. However, the cause of SLD-like lesions found in broilers in Japan still remains unclear.
View Article and Find Full Text PDFAnimals (Basel)
November 2024
Southern Counties Veterinary Specialists, Independent Vetcare (IVC) Evidensia, Forest Corner Farm, Hangersley, Ringwood BH24 3JW, UK.
Bacterial liver parenchymal infections in dogs are rarely documented, and their imaging characteristics are scarce in the veterinary literature, especially in Computed Tomography (CT). This retrospective multicentric study aimed to describe the CT characteristics of parenchymal bacterial liver infection and abscessation in dogs and compare them with the human literature. Twenty dogs met the inclusion criteria.
View Article and Find Full Text PDFMod Pathol
December 2024
Department of Pathology and Molecular Pathology, University Hospital of Zurich, Switzerland; University of Zurich, Switzerland.
While immune checkpoint inhibitors (ICIs) have revolutionized modern oncology, they are also associated with immune-related adverse events (irAEs). Previous histopathological descriptions of organ-related inflammatory changes do not consider systemic effects of ICIs, because of an absence of comprehensive autopsy studies. We performed a retrospective study on 42 whole-body autopsies of patients treated with ICIs from January 2011 to March 2024 to determine frequency, organ distribution and morphology of ICIs-associated inflammatory changes as well as their clinical relevance.
View Article and Find Full Text PDFClin Res Hepatol Gastroenterol
December 2024
Department of Radiology, Institut Curie Saint Cloud, 35 rue Dailly, 92210 Saint Cloud, France.
J Pathol Transl Med
October 2024
Duke-NUS Medical School, Singapore.
Hepatic Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma (EBV+ IFDCS) represents a rare form of liver malignancy. The absence of distinct clinical and radiological characteristics, compounded by its rare occurrence, contributes to a challenging diagnosis. Here, we report a case of a 54-year-old Chinese female with a background of chronic hepatitis B virus treated with entecavir and complicated by advanced fibrosis presenting with a liver mass found on her annual surveillance ultrasound.
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