Dammarane-type triterpene saponins from the roots of Panax notoginseng (Burk.) F. H. Chen and their neuroprotective effects.

Three undescribed dammarane-type triterpene saponins, 20(S)-sanchirhinoside A-A (1-3), together with seventeen known ones, were isolated from the roots of Panax notoginseng (Burk.) F. H. Chen. The chemical structures of the new compounds were determined by HR-MS and NMR experiments along with chemical methods. To the best of our knowledge, compound 1 was the firstly reported fucose-containing triterpene saponin from plants in the genus of Panax. Moreover, the in vitro neuroprotective effects of the isolated compounds were evaluated. Compounds 11-12 displayed remarkable protective effects against PC12 cells injured by 6-hydroxydopamine.