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http://dx.doi.org/10.1684/ejd.2023.4443DOI Listing

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Background: Androgenetic alopecia (AGA) is a common skin disease characterized by gradually miniaturized hair follicles, which manifests as progressive hair thinning and produces a bald appearance. Currently, finasteride is approved by the Food and Drug Administration (FDA) for the treatment of AGA, but its efficacy remains poor in some patients.

Summary: Compared to finasteride, oral dutasteride has better efficacy and similar tolerability, and most adverse events are mild and reversible, making it an effective option for AGA, but its sexual adverse events and potential psychiatric risks still need to be concerned.

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Background: Oral finasteride and topical minoxidil formulations are the only FDA-approved drug therapies for androgenetic alopecia (AGA). Research into dutasteride, topical finasteride, and nontopical minoxidil (low-dose oral and sublingual) formulations in the treatment of AGA has spiked within recent years. Early findings show that these alternative drug therapies may have similar to improved efficacy and safety profiles relative to the conventional treatment options.

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Article Synopsis
  • Mesotherapy is a procedure where lower doses of medication are injected into the skin to treat conditions like hair loss, allowing for longer-lasting effects and improved patient compliance.
  • A systematic review analyzed 27 studies from a pool of 416 records to assess the effectiveness of mesotherapy for hair loss, focusing on various therapeutic agents used in treatment.
  • While some studies indicate significant hair growth improvement from mesotherapy, the lack of standardized treatment protocols and potential side effects highlight the need for more extensive clinical trials.
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Background: Mesotherapy, a technique of transdermal microinjections of specific preparations, is increasingly used in fields such as dermatology and specifically for alopecia treatment. Its popularity stems from its ability to deliver drugs in a targeted manner while minimizing systemic side effects.

Objective: To assess and review current knowledge regarding the use of mesotherapy to deliver alopecia medications and highlight future directions for research.

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