AI Article Synopsis
- Researchers used a synthetic iron-porphyrin catalyst to oxidize the fungicide mandestrobin, successfully removing a xylene group and creating a radiolabeled metabolite.
- The study explored the reaction mechanism by analyzing intermediate compounds and by-products, leading to a better understanding of the process.
- By optimizing reaction conditions, the yield of the desired metabolite increased to 87%, and several carbon-14 labeled versions of the metabolite were synthesized.
Article Abstract
Biomimetic oxidation using synthetic iron-porphyrin (F TPPFeCl) as a catalyst eliminated a xylene moiety of the fungicide mandestrobin, uniformly labeled with carbon-14 at the benzyl ring, to produce the corresponding radiolabeled metabolite 1. This reaction mechanism was investigated by identifying chemical structures of intermediate 5 and p-xyloquinone derivatives 6 and 7, as by-products. Optimization of reaction factors based on the mechanism improved the yield of 1 from mandestrobin up to 87%. Finally, various carbon-14 labeled metabolites of mandestrobin were prepared from 1.
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| http://dx.doi.org/10.1002/jlcr.4044 | DOI Listing |
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