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[Clinical study of Bushen Culuan Formula in treatment of ovulatory disorder infertility caused by hyperprolactinemia].
Zhongguo Zhong Yao Za Zhi
April 2024
China Association of Chinese Medicine Beijing 100029, China.
This paper aims to study the therapeutic effect and safety of Bushen Culuan Formula in the treatment of patients with infertility caused by hyperprolactinemia. Sixty patients with infertility caused by hyperprolactinemia of kidney deficiency and blood stasis were divided into the treatment group(Bushen Culuan Formula + Bromocriptine Mesylate Tablets placebo) and the control group(Bromocriptine Mesylate Tablets + Bushen Culuan Formula placebo), and ovulation rate, pregnancy rate, serum sex hormones, basal body temperature(BBT), and traditional Chinese medicine(TCM) symptom scores were observed. The results showed the clinical effective rate was 90.
View Article and Find Full Text PDF[Study on mechanism of regulation of sex hormones in treatment of hyperprolactinemia-induced ovulatory disorder infertility with Bushen Culuan Formula].
Zhongguo Zhong Yao Za Zhi
April 2024
Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, China.
Transcriptomics was used to investigate the mechanism of action of Bushen Culuan Formula in the treatment of infertility caused by hyperprolactinemia(HPRL), and animal experiments were carried out to verify the results. After establishing an animal model of HPRL-induced infertility, the mice were divided into normal group, model group, Bushen Culuan Formula groups with high-, medium-, and low-doses, and bromocriptine group, and they were observed in terms of the estrous cycle, gonadal index, serum sex hormones, morphology of ovary and mammary gland, follicle count, and fertility. The results showed that the Bushen Culuan Formula could effectively restore the estrous cycle, down-regulate the levels of prolactin(PRL), follicle-stimulating hormone(FSH), and luteinizing hormone(LH), up-regulate the level of estradiol(E_2), increase the number of primordial follicles and sinus follicles, and improve the ovulation rate and fertility of mice.
View Article and Find Full Text PDFSleep duration and association with cardiometabolic health in adolescents and adults with type 1 diabetes: Results from the BCQR-T1D study.
Diabetes Obes Metab
July 2024
Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Aim: Type 1 diabetes (T1D) increases the risk of morbidity and mortality from cardiovascular disease, and insufficient sleep is prevalent. Emerging evidence suggests a link between sleep and cardiometabolic health, but this has not been examined across the lifespan in individuals with T1D. We aimed to examine associations between sleep and cardiometabolic health in adolescents and adults with T1D in a secondary analysis of data from a 4-week double-blind, random-order, placebo-controlled crossover trial of bromocriptine quick release (BCQR) therapy with a 4-week washout in between conditions.
View Article and Find Full Text PDFEffectiveness of pharmacotherapies for diabetes on nicotine, food, and water intake in insulin-resistant rats.
Adv Drug Alcohol Res
January 2024
Department of Psychology, The University of Texas at El Paso, El Paso, TX, United States.
Article Synopsis
- A study was conducted on male and female rats to investigate how diabetes medications interact with nicotine consumption after being placed on a high-fat diet (HFD) or regular diet (RD) for 4 weeks, followed by insulin resistance testing.
- The rats that were on the high-fat diet displayed higher nicotine intake compared to those on the regular diet, and both female and male rats showed similar insulin resistance after receiving a low dose of the diabetes medication streptozotocin (STZ).
- The findings indicated that insulin administration normalized nicotine intake in HFD-fed rats, suggesting that insulin may effectively manage excessive nicotine consumption in individuals with diabetes.
Antipyretic Efficacy of Bromocriptine in Central Fever: an Exploratory Analysis.
Neurocrit Care
October 2023
Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA.
Background: 'Central' fevers are thought to result from disruption of hypothalamic thermoregulatory pathways following severe brain injuries. Bromocriptine, due to its central dopamine receptor agonism, has been hypothesized to have antipyretic effect in this setting. However, clinical evidence for this off-label use is limited to a few case reports.
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