Due to different tensile and compressive properties of rock material, the corresponding tensile and compressive damage evolution show major differences. To investigate the tensile and compressive damage evolution in deep cut blasting with different in-situ stresses, an improved Holmquist-Johnson-Cook (HJC) material model considers the tensile and compressive damage separately is developed. The improved HJC model is implemented into LS-DYNA via a user-defined subroutine in this study. Then, a numerical model with different in-situ stresses loading schemes is modelled. Numerical simulation results show that in-situ stress can inhibit the development of tensile damage evolution, while promote the development of compressive damage evolution. The overall damage zone presents a decreasing trend with the increase of in-situ stress, because the tensile damage is more sensitive than the compressive damage for rock material. In addition, the maximum principal stress can determine the development of the direction of damage. Further, for a field test of blind cut raise in deep, the actual in-situ stress values are loaded on the numerical model. Then, in order to overcome the difficulties caused by in-situ stress, the cut blasting design is optimized by reducing hole spacing. Subsequently, the optimized cut parameters are applied in the blind cut raise. However, the one-step raise excavation method is adjusted to two steps to ensure success due to a serious borehole deviation between drilling and design drawing. After these steps, the formation of the blind cut raise with 8.7 m depth is met the requirements of design.
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http://dx.doi.org/10.3390/ma16093415 | DOI Listing |
Sci Rep
December 2024
Faculty of Natural Sciences, Institute of Biology, Biotechnology and Environmental Protection, University of Silesia in Katowice, Jagiellońska 28, 40-032, Katowice, Poland.
Studies of in situ plant response and adaptation to complex environmental stresses, are crucial for understanding the mechanisms of formation and functioning of ecosystems of anthropogenically transformed habitats. We study short- and long-term responses of photosynthetic apparatus (PSA) and anti-oxidant capacity to complex abiotic stresses of common plants Calamagrostis epigejos and Solidago gigantea in semi-natural (C) and heavy metal contaminated habitats (LZ). We found significant differences in leaf pigment content between both plant species growing on LZ plots and their respective C populations.
View Article and Find Full Text PDFTo address the challenges of performing in-situ tests on riverbed overburden gravel, this study employs three scaling methods-equal mass substitution, similar gradation, and the mixed method-to investigate the original gradation of the gravel. Large-scale triaxial consolidated drained shear tests were conducted to evaluate the effects of the maximum particle size reduction ratio (M) and confining pressure on the stress-strain behavior, fractal dimension, particle breakage, and the parameters of the Duncan-Chang model (an elastic model describing nonlinear stress-strain relationships). The study explores how scaling, based on fractal dimension and particle breakage rate, impacts the strength and deformation characteristics of gravel materials.
View Article and Find Full Text PDFJ Am Chem Soc
December 2024
Department of Chemistry and Center for Emerging Material and Advanced Devices, National Taiwan University, Taipei 106319, Taiwan (R.O.C.).
Reactive carbonyl species (RCS) are important biomarkers of oxidative stress-related diseases because of their highly reactive electrophilic nature. Despite their potential as triggers for prodrug activation, selective labeling approaches for RCS remain limited. Here, we utilized triphenylphosphonium groups to chemoselectively capture RCS via an aqueous Wittig reaction, forming α,β-unsaturated carbonyls that enable further functionalization.
View Article and Find Full Text PDFMol Cell
December 2024
Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue-Straße 3, 60438 Frankfurt am Main, Germany; Institute of Biochemistry, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany. Electronic address:
Changing environmental conditions necessitate rapid adaptation of cytoplasmic and nuclear volumes. We use the slime mold Dictyostelium discoideum, known for its ability to tolerate extreme changes in osmolarity, to assess which role nuclear pore complexes (NPCs) play in achieving nuclear volume adaptation and relieving mechanical stress. We capitalize on the unique properties of D.
View Article and Find Full Text PDFPNAS Nexus
January 2025
School of Chemistry & Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive NW, Atlanta, GA 30332, USA.
Recombinant antibodies are a promising class of therapeutics to treat protein misfolding associated with neurodegenerative diseases, and several antibodies that inhibit aggregation are approved or in clinical trials to treat Alzheimer's disease. Here, we developed antibodies targeting the aggregation-prone β-propeller olfactomedin (OLF) domain of myocilin, variants of which comprise the strongest genetic link to glaucoma and cause early onset vision loss for several million individuals worldwide. Mutant myocilin aggregates intracellularly in the endoplasmic reticulum (ER).
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