AI Article Synopsis

  • * A genome-wide association study (GWAS) of 350 patients undergoing surgery aimed to find SNPs that influence the minimum effective concentration (MEC) of fentanyl post-op.
  • * The study found that the SNP rs966775 was linked to higher MECs of fentanyl, with its minor G allele associated with increased dosages; this has implications for personalized pain management in recovery.

Article Abstract

Sensitivity to opioids varies widely among individuals. To identify potential candidate single-nucleotide polymorphisms (SNPs) that may significantly contribute to individual differences in the minimum effective concentration (MEC) of an opioid, fentanyl, we conducted a three-stage genome-wide association study (GWAS) using whole-genome genotyping arrays in 350 patients who underwent laparoscopic-assisted colectomy. To estimate the MEC of fentanyl, plasma and effect-site concentrations of fentanyl over the 24 h postoperative period were estimated with a pharmacokinetic simulation model based on initial bolus doses and subsequent patient-controlled analgesia doses of fentanyl. Plasma and effect-site MECs of fentanyl were indicated by fentanyl concentrations, estimated immediately before each patient-controlled analgesia dose. The GWAS revealed that an intergenic SNP, rs966775, that mapped to 5p13 had significant associations with the plasma MEC averaged over the 6 h postoperative period and the effect-site MEC averaged over the 12 h postoperative period. The minor G allele of rs966775 was associated with increases in these MECs of fentanyl. The nearest protein-coding gene around this SNP was , encoding the dopamine D receptor. In the gene-based analysis, the association was significant for the gene in the dominant model. Our findings provide valuable information for personalized pain treatment after laparoscopic-assisted colectomy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179231PMC
http://dx.doi.org/10.3390/ijms24098421DOI Listing

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