AI Article Synopsis
- The pulmonary endothelium is crucial for various functions and is affected by conditions like sepsis and acute respiratory distress syndrome.
- Endothelial dysfunction has been linked to severe cases of COVID-19, particularly influencing coagulopathy and other injury markers.
- A comprehensive literature search was conducted up to March 2023 to explore the connection between endothelial biomarkers and the severity of acute and long COVID-19 outcomes.
Article Abstract
The pulmonary endothelium is a highly regulated organ that performs a wide range of functions under physiological and pathological conditions. Since endothelial dysfunction has been demonstrated to play a direct role in sepsis and acute respiratory distress syndrome, its role in COVID-19 has also been extensively investigated. Indeed, apart from the COVID-19-associated coagulopathy biomarkers, new biomarkers were recognised early during the pandemic, including markers of endothelial cell activation or injury. We systematically searched the literature up to 10 March 2023 for studies examining the association between acute and long COVID-19 severity and outcomes and endothelial biomarkers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179170 | PMC |
| http://dx.doi.org/10.3390/ijms24098237 | DOI Listing |
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