An innovative and efficient approach has been developed for the synthesis of 5,6-dihydropyrazolo[5,1-]isoquinolines. This one-pot tandem reaction involves the reaction of ,-cyclic azomethine imines with α,β-unsaturated ketones, using KCO as the base and DDQ as the oxidant. The process results in functionalized 5,6-dihydropyrazolo[5,1-]isoquinolines with good yields. This convenient one-step method encompasses a tandem [3 + 2]-cycloaddition, detosylation, and oxidative aromatization.
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| http://dx.doi.org/10.3390/molecules28093710 | DOI Listing |
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