The assumption that discharge diagnoses of chronic obstructive pulmonary disease and other allied conditions accurately reflect patient medical records was tested using a sample of 553 hospital discharges from the Pittsburgh, Pennsylvania area. Three validation criteria were used in reviewing patient hospital records: 1) the presence of abnormal spirometry test results; 2) reference made to a previous diagnosis of one of the conditions; and 3) reports of respiratory symptoms consistent with these conditions. The findings were that 1 per cent of the 432 cases with a primary diagnosis in this disease category and 10 per cent of the 121 cases with a primary diagnosis of heart disease and a secondary diagnosis in this disease category were not supported by any of the selected criteria.
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http://dx.doi.org/10.2105/ajph.76.7.803 | DOI Listing |
BMC Pulm Med
January 2025
Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Korea.
Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Single-cell RNA sequencing (scRNA-seq) provides gene expression profiles at the single-cell level. Hence, we evaluated gene expression in the peripheral blood of patients with COPD.
View Article and Find Full Text PDFInt Urol Nephrol
January 2025
Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, University of Mansoura, Mansoura, 35516, Egypt.
Aim: Although the relief of ureteral obstruction seems to be a radical treatment for obstructive uropathy (OU), progressive kidney damage is the result because of the associated increased apoptosis and fibrosis. Therefore, it is urgent to find a complementary renoprotective therapy against partially obstructed uropathy cascades. Thus, this study investigated the renoprotective effects of both losartan (LOS) and zinc oxide nanoparticles (ZnONPs) in partial unilateral ureteral obstruction (PUUO).
View Article and Find Full Text PDFSci Rep
January 2025
Division of Pulmonology, Faculty of Medicine, Medical University of Gdańsk, Smoluchowskiego 17, 80-214, Gdańsk, Poland.
Chronic obstructive pulmonary disease (COPD) exacerbations frequently cause patient consultations in both out- and inpatient settings. Recent data suggest that only 40-60% of exacerbations are of bacterial origin and mandate antibiotic treatment. However, a reliable tool to justify prescribing antibiotics for COPD exacerbation is still lacking.
View Article and Find Full Text PDFJ Clin Nurs
January 2025
School of Nursing, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Background: Although several models have been developed to predict postoperative pneumonia in elderly hip fracture patients, no systematic review of the model quality and clinical applicability has been reported.
Objective: To systematically review and critically appraise existing models for postoperative pneumonia in elderly hip fracture patients.
Design: Systematic review and meta-analysis.
Cell Rep Med
January 2025
Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA. Electronic address:
Alpha-1 antitrypsin (AAT) deficiency (AATD) is a monogenic disease caused by misfolding of AAT variants resulting in gain-of-toxic aggregation in the liver and loss of monomer activity in the lung leading to chronic obstructive pulmonary disease (COPD). Using high-throughput screening, we discovered a bioactive natural product, phenethyl isothiocyanate (PEITC), highly enriched in cruciferous vegetables, including watercress and broccoli, which improves the level of monomer secretion and neutrophil elastase (NE) inhibitory activity of AAT-Z through the endoplasmic reticulum (ER) redox sensor protein disulfide isomerase (PDI) A4 (PDIA4). The intracellular polymer burden of AAT-Z can be managed by combination treatment of PEITC and an autophagy activator.
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