AI Article Synopsis
- - Endometriosis is a widespread chronic condition affecting many women, characterized by the growth of uterine-like tissue outside the uterus.
- - Histone deacetylases (HDACs) play a significant role in gene expression by modifying chromatin structure, and their inhibition could offer new treatment options for endometriosis.
- - A comprehensive review of literature highlights the impact of specific HDAC enzymes and their inhibitors on endometriosis, suggesting that targeting these mechanisms could lead to effective therapeutic strategies.
Article Abstract
Endometriosis is a chronic disorder of the female reproductive system which afflicts a great number of women worldwide. Histone deacetylases (HDACs) prevent the relaxation of chromatin, thereby positively or negatively modulating gene transcription. The current review aims at studying the impact of histone modifications and their therapeutic targeting in endometriosis. In order to identify relevant studies, a literature review was conducted using the MEDLINE and LIVIVO databases. The current manuscript represents the most comprehensive, up-to-date review of the literature focusing on the particular role of HDACs and their inhibitors in the context of endometriosis. HDAC1, HDAC2, HDAC3, Sirtuin 1, and Sirtuin 3, are the five most studied HDAC enzymes which seem to, at least partly, influence the pathophysiology of endometriosis. Both well-established and novel HDACIs could possibly represent modern, efficacious anti-endometriotic drug agents. Altogether, histone modifications and their therapeutic targeting have been proven to have a strong impact on endometriosis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177435 | PMC |
| http://dx.doi.org/10.3390/cells12091227 | DOI Listing |
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