AI Article Synopsis
- Biologics targeting IL-17A, IL-23, and TNF-α are effective but often leave residual psoriasis lesions, prompting the need for new topical treatments with different signaling pathways.
- Topical Entinostat, an HDAC1 inhibitor previously used for cancers, showed significant anti-inflammatory effects in mouse models of psoriasis by reducing specific cell infiltrations and inflammatory markers.
- These results indicate that Entinostat could be a valuable new option for treating psoriasis in patients who require additional therapies.
Article Abstract
Background: Biologics against IL-17A, IL-23 and TNF-α achieve a great success in treating psoriasis. However, the majority of patients still have some residual lesions left and require combination therapy to reach complete clearance. Topical medicine is an optional choice but only has limited categories. Besides, drug resistance is very often. Thus, topical medicine targeting new signaling pathway is still in an urgent need in the biologics era.
Objective: To investigate the role of topical Entinostat, a selective inhibitor of histone deacetylases 1 (HDAC1) that has been tested in clinic trials to treat solid tumors and hematological malignancies, in psoriasis therapy.
Methods: Efficacious Entinostat were tested in a mouse imiquimod (IMQ)-induced psoriasiform dermatitis (PsD) model. An in vitro model consisting of human CD4 + T cell, murine T cells and NHEKs were used to screen Entinostat for inhibition of cutaneous inflammatory genes.
Results: Topical application of Entinostat significantly improved psoriasiform inflammation in imiquimod-induced mice model with great reduction of IL-17A+ γδT cell infiltration in skin. Entinostat is powerful agent in inhibition of Th17 cell generation and the expression of psoriasis-related inflammatory mediators by primary keratinocytes upon CD4 T cells stimulation.
Conclusion: Our findings suggest Entinostat is a promising topical medicine for psoriasis treatment.
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| http://dx.doi.org/10.1016/j.jdermsci.2023.05.001 | DOI Listing |
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